Febentel Plus

Febentel Plus is listed by current veterinary-product suppliers as a broad-spectrum antiparasitic combination. Because the official product-specific label was not located, species-specific claims should be confirmed against the supplied pack or veterinary prescription before publication.

• Fenbendazole is used in veterinary medicine against several gastrointestinal worms.
• FDA-approved fenbendazole products for dogs cover roundworms, hookworms, whipworms and certain tapeworms. U.S. Food and Drug Administration
• Ivermectin is used in veterinary medicine against selected susceptible parasites, with indications depending on species and formulation.
• The combination should be used only when a veterinarian considers both active ingredients appropriate for the animal.

The two active ingredients belong to different antiparasitic classes.

Fenbendazole is a benzimidazole anthelmintic that interferes with parasite cellular structures and energy metabolism. Veterinary fenbendazole products are used against several intestinal worms. U.S. Food and Drug Administration

Ivermectin is a macrocyclic lactone that affects chloride channels in susceptible parasites, disrupting nerve and muscle function. Veterinary ivermectin products are used for particular parasites in particular animal species. DailyMed

The combination does not mean that every parasite or every animal species can safely receive the same tablet.

There is not enough reliable product-specific labeling available for Febentel Plus 500 mg + 25 mg to publish a universal dose.

Factor	Why it matters
Animal species	Drug sensitivity and approved uses differ between species
Body weight	Both antiparasitic medicines require weight-appropriate dosing
Parasite	Treatment depends on the identified or suspected parasite
Breed/genetics	Some dogs have increased susceptibility to ivermectin toxicity
Food-producing animals	Meat, milk or other withdrawal requirements may apply

Do not use the 525 mg total tablet strength to calculate an animal's dose. A veterinarian should determine whether this particular combination and strength are appropriate.

• Do not give this product to people. The reviewed evidence identifies Febentel Plus as a veterinary formulation, and fenbendazole is regulated as an animal dewormer in the United States. U.S. Food and Drug Administration
• Ivermectin sensitivity matters in dogs. Collies, Shetland Sheepdogs, Old English Sheepdogs, Australian Shepherd-type dogs and some related dogs can have MDR1 mutations that increase the risk of ivermectin neurotoxicity. Merck Veterinary Manual
• Keep the tablets away from children and people who could accidentally ingest them.
• Do not substitute this combination for a separately prescribed veterinary antiparasitic.
• For cattle, sheep, goats or other food-producing animals, follow the veterinarian's instructions concerning permitted species and withdrawal periods.

Possible adverse effects depend on the animal, parasite, dose and duration of treatment.

For fenbendazole, FDA has reported bone-marrow hypoplasia and pancytopenia in dogs receiving extra-label treatment longer than the labeled duration. The FDA reports involved treatment periods of 5–14 days rather than the labeled 3-day canine regimen. U.S. Food and Drug Administration

Ivermectin toxicity can cause neurological signs. In susceptible dogs, signs can include dilated pupils, ataxia, tremors, collapse, coma and respiratory depression. Merck Veterinary Manual

Store the product according to the actual package instructions, protected from unsuitable heat and moisture and away from children. Because the specific Febentel Plus insert was not located, an exact storage temperature should not be added without checking the supplied packaging.

Febentel Plus should be treated as a veterinary product only. It should not be presented or marketed as a human antiparasitic medicine. The current product image identifies the combination as fenbendazole 500 mg plus ivermectin 25 mg and shows Winlife Pharma branding; current veterinary listings similarly classify the product for animal use. serenepharmaexim.com

Do not administer this product to a human. Fenbendazole is an animal drug, and FDA-approved fenbendazole products have species-specific indications and dosing. U.S. Food and Drug Administration

Veterinary supervision is particularly important for dogs because certain MDR1 gene variants can greatly increase susceptibility to ivermectin toxicity. Merck Veterinary Manual Do not use an ivermectin-containing product without considering the animal's species, breed, weight, health status and other medicines.

If an animal develops severe weakness, dilated pupils, tremors, loss of coordination, unusual sedation, collapse, breathing problems, repeated vomiting or other serious symptoms after treatment, contact a veterinarian or emergency veterinary service immediately.

Do not extend treatment beyond the veterinarian's instructions. FDA has specifically reported serious blood-cell abnormalities associated with prolonged extra-label fenbendazole use in dogs. U.S. Food and Drug Administration

This information is for general education and does not replace advice from a veterinarian or qualified animal-health professional.